Comparation of a direct aspiration first-pass technique (ADAPT) with stent retrievers (SR) for acute stroke therapy

Abstract

Objective To compare ADAPT with stent retrievers for efficacy and safety asa front-line endovascular procedure for the treatment of acute ischemic stroke with large intracranial artery occlusion of the anterior circulation. Methods The clinical data of 33 patients with large intracranial artery occlusions of the anterior circulation who were treated with mechanical thrombectomy by either ADAPT (16 cases) or the stent(17 cases) in our Hospital form June 2018 to October 2019 were retrospectively analyzed. The primary outcome was complete recanalization (modified TICI 2b to 3); secondary outcomes included recanalization time (time from femoral artery puncture to recanalization), clinical outcomes and complication rates (Long-term favorable prognosis rate (mRS score of 0-2 points after 3 months), thrombus escape rate, remedial action rate, bleeding rate, mortality rate, etc.). Results The median baseline NIHSS score was the same for both groups (ADAPT, 13 [interquartile range, 2-23] versus stent, 11 [interquartile range, 3-19]). Recanalization rates (ADAPT, 87.5% versus stent, 70.6%], χ2=1.41, P>0.01) did not differ significantly. Time from groin puncture to recanalization, clinical outcomes and complication rates did not differ significantly between the 2 groups. Conclusions Compared with stent retrievers, ADAPT is effective and safe in the treatment of acute ischemic stroke. However, large sample studies are still needed to further verify the efficacy and safety of thrombus aspiration technology. Key words: ADAPT; Stent retrievers; Efficacy; Safety; Recanalization