Comparasion between effects of lidocaine, magnesium- sulfate and ondansetron on propofol injection pain (lidocaine, magnesium- sulfate, ondasentrone and propofol application)

Abstract

Introduction: This review compares the ondansetron, lidocaine and magnesium-sulfate in the reduction of pain during the introduction with propofol. Methods: The study included 40 patients. Patients were divided into 4 groups: placebo, ondansetron, lidocain and magnesium-sulfate. In addition to pain, heart rate and mean arterial pressure were recorded. Patients allergic to propofol or study drugs, who received regional anesthesia and patients with heart blocks were excluded from the study. Results: The study included 23 males (57.5%) and 17 females (42.5%). There were no statistically significant differences between groups by gender. Pain was reported by 10% of patients who received ondansetron, 20% of patients treated with lidocaine, 10% of patients treated with magnesium-sulfate and 70% of patients who were given placebo, The difference in the incidence of chron- ic pain was statistically significant, p = 0.006. 10% of patients who received ondansetron had moderate pain, 20% of patients treated with lidocaine had mild pain, as well as 10% of patients who were treated with magnesium-sulfate. In relation to this, 20% of patients who received placebo reported a mild pain, 30% severe pain and 20% moderate pain. The difference in the incidence of pain quality was statistically significant p = 0.032. Conclusion: Ondansetron, lidocaine and magnesium-sulfate can prevent propofol injection pain. The study included small number of patients, however, it showed statistically significant differences related to the pain between placebo and study groups.