Abstract
Pellets made from microcyrstalline cellulosem plus dicalcium phosphate dihydrate, lactose and propanolol HCl were compacted on an Integrated Compaction Research System. Several methods including porosity changes, Heckel equation, total work of compaction and average power consumption were used to compare the compaction behavior of the pallets with that of the powers from which they were formed. The effect of external additives and punch velocity on the compaction properties of the pellets was also studied. Significant differences between the compaction properties of the pellets and the powders were observed. It was found that the powders examined compacted by plastic deformation and produced strong compacts, whereas, their pellets exhibited elastic deformation and brittle fragmentation which resulted in compacts of lower tensile strength.
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