COMORBIDITY

Abstract

# P38 MEDIATING ROLE OF ALCOHOL IN THE RELATION BETWEEN SOCIAL ANXIETY, DEPRESSION AND CANNABIS AMONG ADOLESCENTS {#article-title-2} Cannabis use is frequently related to social anxiety and depression among adolescents. Moreover, this substance use is commonly associated with alcohol consumption. A two-year follow-up study was initiated to examine the relationship between cannabis use and social anxiety and depression in adolescents, and to identify potential mediating variables, such as alcohol. Three measures were planned with a year apart. Subjects were 1343 secondary school students aged 15 to 16 years at the baseline examination. The self-administered questionnaire included a set of scales designed to collect socio-demographic data and to assess several variables such as frequency of cannabis use, problems associated with cannabis use, expectations related to cannabis use, alcohol use, trait anxiety, social anxiety, depressive symptoms and social rank. This set of validated scale was administered in the same way in the two subsequent measures. Analyses focused on the data of the first measurement time: (1) epidemiologic data concerning substance use, (2) the relationship between alcohol use and social anxiety (p = .0004; R2 = -.1114), depression (p = .000; R2 = .1474) and other variables, (3) the mediating role of alcohol use in the relation between cannabis use and social anxiety (Z = -3.4048; p = .0007) and depression (Z = 4.5321; p = .000). These results show that the more adolescents express social anxiety, the less they consume alcohol. Inversely, there is a significant positive correlation between alcohol use and depression. In addition, alcohol mediates a part of the relationship between cannabis use and social anxiety/depression. This study will hopefully aid in developing strategies for prevention and early intervention in adolescents. # P39 FUNCTIONAL AND DYSFUNCTIONAL RUMINATION IN ALCOHOL DEPENDENCE {#article-title-3} Previous findings have shown that rumination predicts alcohol abuse independently of depression. However, the literature does not inform about the relationships between alcohol dependence and functional and dysfunctional rumination. It has indeed been suggested that there exist a functional form of rumination, which refers to a concrete, experiential thinking and a dysfunctional form of rumination, which refers to an abstract, analytical thinking. These two forms have been associated with different outcomes in terms of emotional vulnerability, mood, problem solving. In this study, our aim is to evaluate if alcohol dependence is similarly associated with functional/constructive rumination and dysfunctional/ unconstructive rumination. Forty participants (twenty alcohol abusers and twenty healthy subjects) have completed a validated and reliable questionnaire of rumination (the Cambridge Exeter Repetitive Thought Scale) as well as a questionnaire of depression (Beck Depression Inventory). The results have revealed that alcohol abusers have similar levels of functional rumination than healthy participants but report greater tendency for dysfunctional rumination. This effect stays significant after controlling for depression. This study thus supports that rumination is a main feature of alcohol dependence and suggests that it is the dysfunctional rumination that is problematic in alcohol dependence. At a theoretical level, these findings support that there exist two dimensions of rumination. At a clinical level, this study suggests that one should focus on rumination in the treatment of alcohol dependence.