Abstract
High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome. The sample consisted of 32 CHR students, who were screened from 2,800 university students. CHR status was evaluated with the Structured Interview of Prodromal Syndromes, comorbid mental disorder diagnoses with the International Neuropsychiatric Interview. In the CHR sample, 46.9% was found at least one non-psychotic comorbid mental disorder. The CHR participants presenting comorbid mental disorder had significantly more severity of APS than those without comorbid mental disorders, and the remission rate at 6-month follow-up is significantly higher in the individuals without comorbid mental disorders at baseline. In the non-clinical sample of individuals at CHR, non-psychotic comorbid mental disorders are common and anxiety disorder is most frequent. Copresence of anxiety and/or depression is related to higher level of attenuated psychotic symptoms and unfavorable clinical outcome at 6-month follow-up. Assessment and intervention in anxiety and depression for non-clinical CHR adolescents are suggested.
Highlights
Psychoses typically emerge in late adolescence or early adulthood, which are among the main causes of disability in the general population [1]
All the detected subjects at clinical high risk (CHR) state were diagnosed as Attenuated Positive Symptom Prodromal Syndrome (APSS), and seven participants met the criteria for Genetic Risk and Deterioration Prodromal Syndrome (GRDS)
In the 32 CHR subjects, who were screened from 2,800 students, we found a high prevalence (46.9%) of non-psychotic comorbid mental disorder in addition to the at-risk signs and symptoms
Summary
Psychoses typically emerge in late adolescence or early adulthood, which are among the main causes of disability in the general population [1]. Epidemiological research indicates that the majority of individuals first experience mental health symptoms before the age of 24 years [4]. Researchers have suggested that students with mental health problems face high risk of dropping out of college [5]. High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. Little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome
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