Abstract
Studies of the neuropathophysiological mechanisms of chronic epileptic activity, whicharise with the participation of the endogenous histaminergic system of the brain, allowus to justify effective complex means of controlling both convulsive manifestations andcomorbid states, which include sleep and wakefulness disorders.Aim of the work – to study the characteristics of the sleep-wake cycle in rats with PTZinduced kindling under the condition of using the H3 receptor antagonist pitolisant.Methods. The kindling syndrome was induced in Wistar rats by daily administration ofpentylenetetrazole (PTZ) (35.0 mg/kg, i. p.) for three weeks. In rats in the course of kindlingdevelopment, pitolisant (5,0 mg/kg, i. p.) was used for 30 min before epileptogen administration.Research results. In rats with developed kindling, the paradoxical sleep phase wasreduced to 7,1% of the total observation period (4 hours) and its fragmentation increased39,7% and the latent period of paradoxical sleep was 24,0% less compared to the controlgroup (P<0,05). Pitolizant treatment was accompanied by an increase in the durationof the awake phase, which was 29% of the total observation time (P>0,05). At the sametime, the duration of paradoxical sleep was 11,6% (P>0,05), and the slow-wave sleepphase was 71,0% (P>0,05). The number of sleep-wake cycles unreliably exceeded theindicator in the control group 17,2% (P>0,05). Latent periods of falling asleep exceededthe indicator in the control group 44,1% (P<0,05) and at the same time was higher thanin kindling rats 60,2% (P<0,05). The latency period of paradoxical sleep was 34.2%higher than kindling rats (P<0.05). 
 Conclusions. The formation of PTZ-kindling is accompanied by a reduction in the latent period of emergence and the total duration of the paradoxical phase of sleep, as well as an increase in its fragmentation. Blocking of H3 histamine receptors by pitolisan during the formation of kindling by administration of pentylenetetrazol prevents the occurrence of wake-sleep cycle disorders.
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