Abstract
ization time of flight MS, and conclusive protein identifications accomplished by liquid chromatography-tandem MS. Conclusions: Several proteins were reproducibly quantitatively affected by GSE in rat brain, either in abundance, or in isoform complexity. The majority were “old” proteins, i.e. those that had been shown to be differentially expressed in AD or transgenic mouse models of dementia (i.e. creatine kinase brain beta chain, glial fibrillary acidic protein). Because the direction of change for most proteins affected by GSE in the normal healthy rats was opposite to that in AD or transgenic demented mouse brain, administration of GSE to healthy adults to protect critical proteins may be a strategy for prevention of AD.
Published Version
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