Community Involvement in Dengue Outbreak Control: An Integrated Rigorous Intervention Strategy.

Hualiang Lin,Haojie Zhong,Lifeng Lin,Jinyan Lin,Tao Liu,Jianpeng Xiao,Zhiqiang Peng,Tie Song,Wenjun Ma,Yonghui Zhang,Jianfeng He,Aiping Deng,Wenbiao Hu,Eva Harris

doi:10.1371/journal.pntd.0004919

Abstract

BackgroundAn explosive outbreak of dengue fever occurred in Guangdong Province, China in 2014. A community-based integrated intervention was applied to control this outbreak in the capital city Guangzhou, where dengue epidemic was mainly caused by imported cases.Methodology/Principal FindingsWe used a time series generalized additive model based on meteorological factors to assess the effectiveness of this intervention. The results showed that there was significant reduction in mosquito density following the intervention, and there was a 70.47% (95% confidence interval: 66.07%, 74.88%) reduction in the reported dengue cases compared with the predicted cases after 12 days since the beginning of the intervention, we estimated that a total of 23,302 dengue cases were prevented.ConclusionsThis study suggests that an integrated dengue intervention program has significant effects to control a dengue outbreak in areas where dengue epidemic was mainly caused by imported dengue cases.

Highlights

Dengue fever, a mosquito-borne viral disease caused by any of the four dengue virus serotypes, is regarded as one of the most important arboviral diseases globally [1]
This study suggests that an integrated dengue intervention program has significant effects to control a dengue outbreak in areas where dengue epidemic was mainly caused by imported dengue cases
The analysis showed that there was significant reduction in mosquito density following the intervention (Breteau Index (BI) reduced from 10.88 to 2.11), and there was a 70.47% (95% confidence interval: 66.07%, 74.88%) reduction in the reported dengue cases compared with the predicted cases after 12 days since the beginning of the intervention

Summary

Introduction

A mosquito-borne viral disease caused by any of the four dengue virus serotypes, is regarded as one of the most important arboviral diseases globally [1]. Guangdong Province has the highest dengue infestation level in mainland China [5]. In 1978, dengue fever re-emerged in Guangdong Province after disappearing for about 30 years in mainland China. Since it occurred in Guangdong almost every year [6,7]. The dengue cases in this province were mainly caused by imported cases from surrounding dengue endemic countries and areas [8]. An explosive outbreak of dengue fever occurred in Guangdong Province, China in 2014. A community-based integrated intervention was applied to control this outbreak in the capital city Guangzhou, where dengue epidemic was mainly caused by imported cases

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Conclusion