Abstract
This study aims to determine the genital HPV prevalence in reproductive-age women in Thua Thien Hue Province and comparison with HPV incidence in Hue University Hospital, Vietnam. Cross-sectional study on 1,034 women of reproductive age from 11 communes/wards of three districts representing three different geographic areas of Thua Thien Hue Province, Vietnam. The hospital-based group included 102 women with cervicitis and/or abnormal Pap smear result coming to Hue University Hospital. Extracting DNA from cervical samples, performing the real-time PCR for detecting HPV and the reverse dot-blot assay for HPV typing in HPV positive cases. In community, HPV prevalence was 0.9%. Mean-age of HPV positive group was 37.9 ± 6.2 years. The detected low-risk types were 6 and 11; high-risk types include 16, 18, 33, 45, 52, and 58. Single-type infection was found in 66.7% of cases. In hospital-based group, 41.2% of women have been infected with HPV, 6 different HPV types were detected. HPV18 was the most frequent high-risk type (33.3%), followed by HPV16 (15.1%); HPV6 was the most frequent among low-risk HPV types (31.2%). Single-type infection rate was 33,3%; 2 and 3 types co-infections were 28,6% and 38.1%, respectively. Routine screening of high-risk HPV infection in women with symptomatic gynecologic infection and/or abnormal Pap smear appears to be benefit in early detection and prevention of cervical cancer, due to the high incidence of HPV infection.
Highlights
This study aims to determine the genital HPV prevalence in reproductive-age women in Thua Thien Hue Province and comparison with HPV incidence in Hue University Hospital, Vietnam
According to World Health Organization, cervical cancer is the second most common cancer in women living in less developed regions with an estimated 445,000 new cases in 2012 (84% of the new cases worldwide); approximately 270,000 women died from cervical cancer, more than 85% of these deaths occurring in low- and middle-income countries [1]
Data from medical literature with hundreds of observational studies and 6 randomized controlled trials recommend the importance role of HPV testing as a primary screening tool for early detection of cervical cancer precursors [4]; local evidence from community-based HPV testing and the actual HPV infection prevalence are still needed, in order to assess the role of mass screening by HPV testing
Summary
This study aims to determine the genital HPV prevalence in reproductive-age women in Thua Thien Hue Province and comparison with HPV incidence in Hue University Hospital, Vietnam. Cervical cancer incidence in developed countries is very low, thanks to the effective and efficient organized mass screening program and appropriate intervention after detection of abnormal cases [1]. Data from medical literature with hundreds of observational studies and 6 randomized controlled trials recommend the importance role of HPV testing as a primary screening tool for early detection of cervical cancer precursors [4]; local evidence from community-based HPV testing and the actual HPV infection prevalence are still needed, in order to assess the role of mass screening by HPV testing
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