Abstract
BackgroundWe characterized 100 USA100 epidemic MRSA from individuals in the community with no known healthcare-associated risk factors.FindingsMolecular epidemiology demonstrated 21 pulsed-field types and six spa types. SCCmec typing demonstrated that all of the strains possess the type II cassette. The staphylococcal enterotoxin D virulence gene was also present.ConclusionCharacterization of USA100 MRSA in the community illustrated the importance of nasal carriage, and the genetic diversity of the USA100 clone.
Highlights
We characterized 100 USA100 epidemic methicillin-resistant S. aureus (MRSA) from individuals in the community with no known healthcare-associated risk factors
The majority of isolates added to our collection are USA300 MRSA, we have identified a large number of USA100 MRSA from the same population
Previous studies have demonstrated USA100 MRSA are relatively uniform in SCCmec type and spa genes, typically containing SCCmec II and spa type 2 (TJMBMDMGMK) (McDougal et al 2003; Limbago et al 2009; Tenover et al 2008)
Summary
We characterized 100 USA100 epidemic MRSA from individuals in the community with no known healthcare-associated risk factors. USA100 is considered an HA-MRSA and a cause of invasive infection primarily among persons with healthcare-associated risk factors (Klevens et al 2007; Limbago et al 2009). Detected in nasal swabs from non-institutionalized individuals (Tenover et al 2008), USA100 MRSA have not been well described in the community environment, the goal of the present study.
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