Abstract
Objective: About 10% of epithelial ovarian cancers arise in women with mutations in high penetrance genes (BRCA1/2), but these account for only about 40% of excess familial risk. The Ovarian Cancer Association Consortium (OCAC) has previously found 6 common single nucleotide polymorphisms (SNPs) using genome wide association studies (GWAS) that increase overall and serous ovarian cancer risk, but these only account for an additional 4% of familial risk. The Collaborative Oncological Gene-Environment Study (COGS), an ovarian, breast and prostate cancer consortium, sought to validate additional risk SNPs at a genome wide level of significance.
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