Abstract
BackgroundObesity causes severe healthcare problem worldwide leading to numerous diseases, such as cardiovascular diseases and diabetes mellitus. Previous Genome-Wide Association Study (GWAS) identified an association between a single nucleotide polymorphism (SNP) rs7138803, on chromosome 12q13 and obesity in European Caucasians. Since the genetic architecture governing the obesity may vary among different populations, we investigate the variant rs7138803 in Chinese population to find out whether it is associated with obesity.MethodsA population-based cohort association study was carried out using the High Resolution Melt (HRM) method with 1851 participants. The association between rs7138803 genotypes and body mass index (BMI) was modeled with a general linear model, and a case–control study for the association between rs7138803 genotypes and obesity was performed using Pearson’s χ2 test. There was no indication of a deviation from Hardy-Weinberg equilibrium (HWE p value = 0.51) in our sample.ResultsNo association was detected between SNP rs7138803 and BMI in our Chinese Han population with a P value of 0.51. SNP rs7138803 was found to be not associated with common forms of obesity after adjusting for age and sex in the Chinese population. SNP rs7138803 was not associated with other obesity related traits, including T2DM, hypertension, lipid profiles, and ischemic stroke.ConclusionOur data suggest that the rs7138803 exerts no significant effect on obesity in Chinese Han population. Larger cohorts may be more appropriate to detect an effect of this SNP on common obesity.
Highlights
Obesity causes severe healthcare problem worldwide leading to numerous diseases, such as cardiovascular diseases and diabetes mellitus
single nucleotide polymorphism (SNP) rs7138803 was genotyped in totally 1,851 subjects, all subjects are of the ethnic Han origin according to medical files, 543 subjects were recruited from WD-Coronary artery disease (CAD) study and 1308 subjects were from Beijing stroke cohort (BJSC) study
Since there was possible significant correlation between body mass index (BMI) and lipid profiles, we investigated the potential association of total cholesterol (TC), triglyceride (TG), HDL-cholesterol and LDL-cholesterol with rs7138803, but no significant association was demonstrated after carrying out quantitative association analysis in our study (Table 3)
Summary
Obesity causes severe healthcare problem worldwide leading to numerous diseases, such as cardiovascular diseases and diabetes mellitus. Since the genetic architecture governing the obesity may vary among different populations, we investigate the variant rs7138803 in Chinese population to find out whether it is associated with obesity. Obesity predisposes to type 2 diabetes mellitus (T2DM), cardiovascular diseases, dyslipidemia, hypertension, sleep apnea and some forms of cancer [2]. A number of studies have pointed toward a strong hereditary component of obesity, identifying genetic variants that influence human BMI will advance our understanding of how environmental and genetic factors interplay together to lead to obesity. Huge progresses based on the large scale association have been made on the susceptibility genes linked to obesity.
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