Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes.

Wei-Hao Hsu,Mei-Yueh Lee,Yu-Ting Huang,Ching-Chao Liang,Szu-Chia Chen,Chin-Wei Tseng

doi:10.3390/healthcare9081010

Abstract

Prediabetes should be viewed as an increased risk for diabetes and cardiovascular disease. In this study, we investigated its prevalence among the relatives and spouses of patients with type 2 diabetes or risk factors for prediabetes, insulin resistance, and β-cell function. A total of 175 individuals were included and stratified into three groups: controls, and relatives and spouses of type 2 diabetic patients. We compared clinical characteristics consisting of a homeostatic model assessment for insulin resistance (HOMA-IR) and beta cell function (HOMA-β), a quantitative insulin sensitivity check index (QUICKI), and triglyceride glucose (TyG) index. After a multivariable linear regression analysis, the relative group was independently correlated with high fasting glucose, a high TyG index, and low β-cell function; the relatives and spouses were independently associated with a low QUICKI. The relatives and spouses equally had a higher prevalence of prediabetes. These study also indicated that the relatives had multiple factors predicting the development of diabetes mellitus, and that the spouses may share a number of common environmental factors associated with low insulin sensitivity.

Highlights

Prediabetes is typically defined as a higher blood glucose level than normal, but lower than the threshold for the criterion of diabetes [1]
The relatives and spouses of type 2 diabetic patients in this study had a high prevalence of prediabetes
Being a relative was significantly associated with high fasting blood glucose, a high triglyceride glucose (TyG) index, low β-cell function, and low quantitative insulin sensitivity check index (QUICKI), whereas being the spouse of a type 2 diabetic patient was only significantly associated with low QUICKI (Table 10)

Summary

Introduction

Prediabetes is typically defined as a higher blood glucose level than normal, but lower than the threshold for the criterion of diabetes [1]. A family history of diabetes has been shown to be a strong risk factor type 2 diabetes, which may at least partially be due to shared genetic and environmental factors [5,6], which was the finding of a U.S population study [7]. This indicated that the risk of developing type 2 diabetes increased with the number of family members that had it. We investigated the prevalence of prediabetes in the relatives and spouses of type 2 diabetes patients and the risk factors for prediabetes, insulin resistance, and β-cell function in these populations

Methods

Results

Discussion

Conclusion