Abstract
In obstetrics, commonly involved lower limbs neuropathies are peroneal, sciatic and femoral nerves but peroneal nerve palsy is the most common. Causes of peroneal nerve injury during childbirth include, but not limited to, instrument-assisted delivery, prolonged external knee compression from stirrups or hand positioning, knee hyperflexion, prolonged squatting and sometimes neuraxial anaesthetic technique. We present a case of unilateral common peroneal neuropathy in a vaginal delivery patient under epidural technique.
Highlights
Lissencephaly(LIS), a combination of two Greek words (Lissos= smooth: Encephalin=brain),is a developmental anomaly of brain resulting from abnormalities of neuronal migration[1] and is characterized by absent or broad, flat and thick gyri.It is a rare disease with a prevalence rate of 12 per million births[2]
Ms SC,a 17 years old girl was admitted in Neurology centreof Collage of Medical Sciences (COMS),Bharatpur, (ChitwanDistrict), Nepal on 16 January 2016 following a seizure episode
EEG (Figure-1) showed dysrhythmia withfrequent seizure discharges arising from both sides.No phenomenon of phase reversal, periodic discharges or suppression burst noted.MRI (Figure-2) revealed abnormally thickened gyrus (Pachygyria)involving insular, temporal and parietal region
Summary
ABSTRACT “Lissencephaly”, a raregenelinked defective neuroblastmigration disorder resulting in defective cortical lamination, abnormal gyral development and subcortical heterotropia.Advances in molecular genetics have led to the identification of lissencephaly gene onchromosome 17p13.3and causing Type-1 Lissencephaly or miller Diecker syndrome where lissencephaly is severe in posterior brain region. Another X-linked gene Doublecortin (DCX) gene where the lissencephalyis more severe in anterior region of thebrain. A case of lissencephaly with features of Miller Diekersyndrome in a young girl is reported and literature is reviewed.
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