Abstract
Despite numerous studies investigating resilience and personality trials, a paucity of information regarding their neurobiological commonalities at the level of the large resting-state networks (rsNWs) remains. Here we address this topic using the advantages of ultra-high-field (UHF) 7T-MRI, characterized by higher signal-to-noise ratio and increased sensitivity. The association between resilience, personality traits and three fMRI measures (fractional amplitude of low-frequency fluctuations (fALFF), degree centrality (DC) and regional homogeneity (ReHo)) determined for three core rsNWs (default mode (DMN), salience (SN), and central executive network (CEN)) were examined in 32 healthy volunteers. The investigation revealed a significant role of SN in both resilience and personality traits and a tight association of the DMN with resilience. DC in CEN emerged as a significant moderator for the correlations of resilience with the personality traits of neuroticism and extraversion. Our results indicate that the common neurobiological basis of resilience and the Big Five personality traits may be reflected at the level of the core rsNWs.
Highlights
Despite numerous studies investigating resilience and personality trials, a paucity of information regarding their neurobiological commonalities at the level of the large resting-state networks remains
All of the participants were healthy according to the Structured Clinical Interview for DSM-IV (SCID-I)
We examined the resting-state activity (RSA) and FC within the three resting-state networks (rsNWs) that provide the basis of the triple network model (TNM)
Summary
Despite numerous studies investigating resilience and personality trials, a paucity of information regarding their neurobiological commonalities at the level of the large resting-state networks (rsNWs) remains We address this topic using the advantages of ultra-high-field (UHF) 7T-MRI, characterized by higher signal-to-noise ratio and increased sensitivity. One of the main advantages of this new technology is a more sensitive observable blood oxygenation level-dependent (BOLD) contrast change, as a result of increased susceptibility effects at UHF This reduces nonspecific mapping signals from large vessels and accentuated microvasculature contributions and enables significantly improved functional MRI (fMRI) experiments[1]. In the field of mental health, a deeper understanding of the psychological adjustment processes is crucial in order to identify protective factors preventing mental diseases In this context, in recent decades numerous neuroscientists have dedicated their efforts to the topic of resilience. (personality traits, individual resources), biological, and environmental (social and family relationships, society and culture) factors[9] which all influence each other in a most sophisticated way
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