Abstract
Aim: Lysosomal acid lipase (LAL), coded by LIPA gene, has critical role in cholesterol-ester metabolism in LDL receptor pathway. LIPA is a susceptibility gene for CAD in GWAS studies, as LIPA SNP with increased expression shows increased CAD risk. LAL activates SREBP and LXR, and LAL deficiency shows non-HDL overproduction and HDL reduction. LAL showed lipotoxicity in pancreas ß-cells. However, little is known about physiological LAL activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
