Abstract
Common Disease, Multiple Rare (and Distant) Variants
Highlights
Genome-wide association (GWA) studies have emerged as a potentially powerful tool for discovery of new genes for common diseases, such as Alzheimer’s disease and stroke
The common interpretation of GWA findings might be incorrect in many cases, according to a new study by Samuel Dickson, David Goldstein, and colleagues in this issue of PLoS Biology
Their results suggest that the signals in these studies may not always be pointing to a few common gene variants, as assumed by most researchers, but instead to many rare variants, each of which causes relatively few cases, and each of which may be relatively far away from the site identified in the GWA study
Summary
Genome-wide association (GWA) studies have emerged as a potentially powerful tool for discovery of new genes for common diseases, such as Alzheimer’s disease and stroke. The common interpretation of GWA findings might be incorrect in many cases, according to a new study by Samuel Dickson, David Goldstein, and colleagues in this issue of PLoS Biology.
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