Abstract
Common Disease: Are Causative Alleles Common or Rare?
Highlights
It has been said that a week is a long time in politics
Using arguments based on population genetics [1], the CD-CV hypothesis proposed that in common diseases with a genetic component, some predisposing alleles are relatively common and a combination of alleles or environmental effects was required before disease occurred, much like being dealt a bad hand from a common deck of cards
Others cast doubt on this idea and suggested that common diseases are unlikely to be caused by common alleles and more likely to be caused by rarer ones; they too deployed arguments based on population genetics and suggested that association studies using common genetic variants might not be successful [2,3]
Summary
It has been said that a week is a long time in politics. But in human disease gene mapping, 10 years can seem a very short time . Some readers might recall the heated debates about the common disease, common variant (CD-CV) hypothesis.
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