Abstract
Systems Immunology Cytotoxic CD4+ T cells (CD4-CTLs) were initially identified in patients with chronic viral infections, including dengue virus infection. Patil et al. sequenced the T cell receptors of individual CD4+ T cells from human blood to identify precursors that give rise to CD4-CTL cells. CD4-CTL cells underwent marked clonal expansion, and CD4-CTL precursor cells were characterized by high expression of interleukin-7 receptor. These findings should facilitate improved vaccine design in the context of chronic viral infections. Sci. Immunol. 3 , eaan8664 (2018).
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