Abstract

Dear Dr. Visek: It has been suggested that a record be made of some data obtained during the latter days of the study of vitamin E sponsored by the Food and Nutrition Board of the National Research Council (1). The data ob tained (now in SI units) on cholesterol in the plasma were not a part of the main protocol, and, although they have been used in oral presentations, they have not previously appeared in print. The subjects, all males, were fed a controlled diet daily of natural foods formulated to contain 9614 kj (2300 kcal) in a closed metabolic unit (Table 1). The fat in the diet contained 60 g of commercial corn oil, which was replaced with 60 g of beef fat (stearin) after 7 mo. Nothing new is claimed but the data, although sparse, do reinforce the following conceptions: 1) Older men tend to have higher levels of plasma cholesterol. 2) A few days of a change in diet from more unsaturated fats to less unsaturated fat can have a marked effect on the level of cholesterol in the blood. 3) Five of the eight subjects had higher levels of plasma tocopherols after being fed the diet con taining beef fat despite the much higher level of tocopherols in com oil. The significance of this did not become apparent until after our research on the relationship of the level of vitamin E to lipids in the blood (2).

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