Abstract

There is evidence that both the noradrenergic and serotonergic systems participate in mediating the loss of regular estrous cycles in old female rats. The decrease in noradrenergic activity appears to be more important than the possible increase in serotonergic activity, since noradrenaline has been reported' to facilitate LH release under most conditions, whereas 5-HT has been shown to inhibit LH release under many but not all conditions. In addition, changes in other hypothalamic neurotransmitters, in high prolactin and low thyroxine secretion, and in pituitary responsiveness to GnRH, may also be involved in the loss of estrous cyclicity in old rats.

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