Comments on "Injection Lipolysis With Phosphatidylcholine and Deoxycholate"

Abstract

In a previous letter to the editor, Hasengschwandtner and Gundermann1 raised the question of sodium deoxycholate's (DC) unselective action when injected subcutaneously during nonsurgical, localized fat reduction, to support their theory that phosphatidylcholine (PC) provides an indispensable adjunct to reduce DC toxicity. Although DC's efficacy on cell lysis has been scientifically2,3 and clinically4,5 proven, its unselective action5–8 has been widely debated. When assessed at various DC:PC ratios, PC demonstrates antilipolytic action,9 with the ability to reduce DC's aggressiveness (Figure 1) (A. Rotunda, personal communication, 2006). Figure 1 Cytolytic activity of sodium deoxycholate in adipocytes attenuated by phosphatidylcholine. Sodium deoxycholate is indicated …