Abstract
Recent articles have investigated the change in the microdosimetric characteristics of a neutron therapy beam when the target tissues are loaded with boron. These measurements yield information on the physical dose, and the single event distributions seen by average tissue regions with micron dimensions. However, the extrapolation from this information to a reflection of the overall effectiveness of the treatment is fraught with problems. The determination of a factor for each boron-loaded compound, which combines the effects of the LET of the reaction products, and the microdistribution that the boron takes up in different tissues, is essential in assessing the effectiveness of boron loading on the overall efficacy of the therapy modality.
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