Abstract
Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity.
Highlights
The life expectancy in the world’s population is increasing, highlighting the need of better understanding of the cellular and molecular pathways that drive the aging process
IRE1 is the only endoplasmic reticulum (ER) stress sensor expressed in yeast and contributes to lifespan extension (Labunskyy et al, 2014), consistent with the fact that unfolded protein response (UPR) activation in this organism is a relevant feature involved in the health span control triggered by caloric restriction (Choi et al, 2013)
Another report indicated that the ectopic expression of XBP1s in neurons has a significant effect in increasing lifespan in C. elegans, representing one of the strongest aging modulator described so far in this specie (Taylor and Dillin, 2013)
Summary
The life expectancy in the world’s population is increasing, highlighting the need of better understanding of the cellular and molecular pathways that drive the aging process. A commentary on XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity by Taylor, R. ER stress triggers the activation of the unfolded protein response (UPR), a central homeostatic pathway that orchestrates cells adaptation (Hetz et al, 2015).
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