Abstract
Commentary: Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates.
Highlights
Meningitis and/or septicemia caused by Neisseria meningitidis remains a serious public health concern
After screening 18 meningitidis serogroup B (MenB) strains, the authors provide data illustrating that factor H binding protein (FHbp) variants coding for classes SP2-SP4 are not exported to the cell surface via the traditional lipoprotein pathway
FHbp-specific monoclonal antibodies were used to conclude that strains expressing SP2-4 FHbp variants were less susceptible in hSBAs than strains expressing SP1 FHbp variants
Summary
Meningitis and/or septicemia caused by Neisseria meningitidis remains a serious public health concern. A Commentary on Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates by da Silva, R. Both vaccines were licensed based on the demonstration that they induce antibody responses that kill MenB isolates in serum bactericidal activity assays using human complement (hSBA).
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