Abstract
Commentary: Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal.
Highlights
The authors have flash-lighted on utility of different synthetic biological and system biological based metabolic engineering techniques for harnessing the biosynthetic capabilities of Streptomyces
Genome mining has revealed that Streptomyces can harbor numerous active or cryptic biosynthetic gene clusters encoding for diverse compounds including novel antimicrobials (Chaudhary et al, 2013)
Bioinformatics tools assisting on studies rendering to structure-activity relationships (SAR) or quantitative structure activity relationship (QSAR) can assist in developing the effective drug molecules from microbial resources
Summary
A commentary on Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal by Antoraz, S., Santamaría, R. The discovery of new antimicrobials and expansion of utility of existing antibiotics by overproduction or targeted modification is crucial to combat the ever-increasing antimicrobial resistance (Dhakal et al, 2015; Lin et al, 2015). Streptomyces is the major sources of natural products including effective antimicrobials (Chaudhary et al, 2013).
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