Abstract
Commentary: "The Etiology of Down Syndrome"
Highlights
It is well known that most Down Syndrome cases are of maternal origin, and that the likelihood of having a child with Trisomy 21 increases with maternal age
We have tested the possibility that the extra chromosome in Trisomy 21 Down syndrome may be due to a segregation problem, taking place during fetal mitotic oogonial cell divisions
We have analysed the chromosome constitution in 27150 pre-meiotic oogonia from 26 fetal ovarian samples with FISH technique and found that the incidence of Trisomy 21 cell nuclei is raised at later stages of fetal oogonial development
Summary
It is well known that most Down Syndrome cases are of maternal origin, and that the likelihood of having a child with Trisomy 21 increases with maternal age. We have tested the possibility that the extra chromosome in Trisomy 21 Down syndrome may be due to a segregation problem, taking place during fetal mitotic oogonial cell divisions. We have analysed the chromosome constitution in 27150 pre-meiotic oogonia from 26 fetal ovarian samples with FISH technique and found that the incidence of Trisomy 21 cell nuclei is raised at later stages of fetal oogonial development.
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