Abstract
Commentary: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore.
Highlights
Specialty section: This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology
The Authors conclude that SPG7 is an Commentary: SPG7 and permeability transition pore essential component of the PTP complex together with VDAC1, but from analysis of the results we must conclude that this is an overinterpretation that is not supported by the experimental results presented
The results show that the PTP opened, albeit at higher Ca2+ loads, after suppression of all 13 transcripts including SPG7 (Shanmughapriya et al, 2015)
Summary
Specialty section: This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology. SPG7 is an essential and conserved component of the mitochondrial permeability transition pore.
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