Commentary: Spatiotemporal Modeling of the Key Migratory Events During the Initiation of Adaptive Immunity.

Johannes U Mayer

doi:10.3389/fimmu.2019.02311

Abstract

Commentary: Spatiotemporal Modeling of the Key Migratory Events During the Initiation of Adaptive Immunity.

Highlights

Reviewed by: Vuk Cerovic, RWTH Aachen University, Germany Behazine Combadiere, Institut National de la Santé et de la Recherche
A large proportion consists of different populations of conventional dendritic cells, which migrate through the lymphatics to transport antigen from the periphery to the lymph node where they present antigen peptides to naïve T cells to initiate adaptive immunity [recently reviewed in Worbs et al [4] and Randolph et al [5]]
Antigen positive neutrophils, monocyte derived dendritic cells, and monocytes have been identified in the lymph node under certain conditions [6,7,8,9], but defining their migration kinetics and origin remains challenging

Summary

Introduction

Reviewed by: Vuk Cerovic, RWTH Aachen University, Germany Behazine Combadiere, Institut National de la Santé et de la Recherche. A large proportion consists of different populations of conventional dendritic cells, which migrate through the lymphatics to transport antigen from the periphery to the lymph node where they present antigen peptides to naïve T cells to initiate adaptive immunity [recently reviewed in Worbs et al [4] and Randolph et al [5]].

Results

Conclusion