Commentary: Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons.

Matthew William,Victoria Cegielski,Xiang-Ping Chu

doi:10.3389/fncel.2021.714204

Matthew William, Victoria Cegielski + Show 1 more

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https://doi.org/10.3389/fncel.2021.714204

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Abstract

Commentary: Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons.

Highlights

Multiple disorders are associated with a decrease in cerebral extracellular pH, including brain ischemia, seizures, and neurodegenerative diseases like multiple sclerosis (Vergo et al, 2011; Chu and Xiong, 2012; Friese et al, 2014; Leng et al, 2014; Tóth et al, 2020)
The results suggest that the presence and functionality of ASIC1a plays a critical role in producing action potential (AP) in cortical neurons
Future studies should be conducted to identify the effects of this increased AP duration, and how it contributes to the pathology of diseases that involve intermediately slow acidification

Summary

Introduction

Multiple disorders are associated with a decrease in cerebral extracellular pH, including brain ischemia, seizures, and neurodegenerative diseases like multiple sclerosis (Vergo et al, 2011; Chu and Xiong, 2012; Friese et al, 2014; Leng et al, 2014; Tóth et al, 2020). Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons. A Commentary on Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons by Alijevic, O., Bignucolo, O., Hichri, E., Peng, Z., Kucera, J.

Results

Conclusion