Commentary: Preservation of a remote fear memory requires new myelin formation.

Yini Li,Haibo Shi

doi:10.3389/fncir.2020.00028

Abstract

Commentary: Preservation of a remote fear memory requires new myelin formation.

Highlights

Memory is not permanently fixed, but can be updated by experience continuously
Several studies highlighted the roles of new myelin formation in memory processing, especially in reconsolidation of remote memory (Pan et al, 2020; Steadman et al, 2020)
Results showed that reduced adult oligodendrogenesis during immediate but not later post-training period impaired both spatial learning and memory consolidation, suggesting a temporal control for efficient myelination as an adaptive response to neural circuit activities

Summary

Introduction

Memory is not permanently fixed, but can be updated by experience continuously. This process requires synaptic reorganization of neural circuits, such as synaptic plasticity. A Commentary on Preservation of a remote fear memory requires new myelin formation by Pan, S., Mayoral, S. Accumulating evidence demonstrated that oligodendrogenesis is regulated by neuronal activity and plays important roles in experience-dependent learning, such as through de novo myelination with temporal precision (Gibson et al, 2014; McKenzie et al, 2014; Mensch et al, 2015; Xiao et al, 2016).

Results

Conclusion