Abstract
Commentary: Prenatal Ethanol Exposure Persistently Alters Endocannabinoid Signaling and Endocannabinioid-Mediated Excitatory Synaptic Plasticity in Ventral Tegmental Area Dopamine Neurons.
Highlights
Medical University of South Carolina, United States David M
This reinforcement driving drugseeking behaviors is thought to result from the imbalance in glutamate homeostasis that disrupts the mesocorticolimbic dopamine (DA) pathways (Kalivas, 2009)
Positive Reinforcement in Drug Addiction by chronic ethanol administration (Basavarajappa and Hungund, 1999; Xia et al, 2006; Mitrirattanakul et al, 2007; DePoy et al, 2013; Varodayan et al, 2016). eCB-long-term depression (LTD) in midbrain DA neurons was mediated by reduced presynaptic glutamate release (HajDahmane and Shen, 2010)
Summary
Medical University of South Carolina, United States David M. Prenatal Ethanol Exposure Persistently Alters Endocannabinoid Signaling and Endocannabinoid-Mediated Excitatory Synaptic Plasticity in Ventral Tegmental Area Dopamine Neurons by Hausknecht, K., Shen, Y.-L., Wang, R.-X., Haj-Dahmane, S., and Shen R.-Y. Expanding this line of research, a recent work (Hausknecht et al, 2017) discovered that PE exposure persistently impaired eCB long-term depression (LTD) at excitatory synapses in rats.
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