Commentary: Physiological Intracytoplasmic Sperm Injection (PICSI), An Alternative to the Standard ICSI Procedure

Abstract

The rationale of this study is to uncover sperm selection by hyaluronic acid (HA) binding which could advance fertilization pace and embryo quality in Intracytoplasmic sperm injection (ICSI) cycles. HA a sperm binding nonsulfated glycosaminoglycan required as a part of normal fertilisation. Physiological Intracytoplasmic Sperm Injection employs sperm binding to Hyaluronic acid to opt for which sperm to use for Intracytoplasmic sperm injection. PICSI and their latent benefit are still in tranquil being explored. We expect more detailed facts in the coming few years in relation to for whom these modus operandi are most useful apart from cases discussed. Usually if the sperm binding is less than 65% the PICSI dish is used to select the sperm. The medley of sperm selection for ICSI is essential and directly authorise the male input to the embryo therefore visual evaluation alone should certainly not be the only aspect involved when selecting a sperm for ICSI failed cycle twice. But unfit sperm with DNA fragmentation and compromised maturity is able to appear normal and healthy, but if selected for injection/insemination can go ahead to deprived embryo quality and likely a pregnancy loss.