Abstract
I commend the authors on their thorough review of cryotherapy for noninvasive localized subcutaneous fat reduction.1 Data from almost 1500 subjects across multiple body sites demonstrate that, due to its intrinsic cold-sensitivity, lipid-rich subcutaneous tissue can be preferentially targeted without damage to surrounding water-rich structures. Yet, despite all of the evidence regarding the safety and efficacy of this modality, the underlying mechanisms by which its clinical effects occur have yet to be completely elucidated. Manstein et al2 evaluated previously treated (frozen, then thawed) pig lard, providing the first evidence that …
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