Commentary on “Interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury”

Abstract

Ischemia/reperfusion (I/R) injury represents an extremely active field of basic science research. The reason is that it involves a complex series of events with multiple protagonists (which have not been well defined yet), as well as the fact that it is an event common in a variety of clinical situations, including transplantation, liver resection, trauma, and vascular surgery. The basic mechanism is that of the sequence of ischemia, followed by the return of blood flow, with the reperfusion causing the activation of inflammatory cascades.