Commentary on: Exposure to Tumescent Solution Significantly Increases Phosphorylation of Perilipin in Adipocytes.

Abstract

The article “Exposure to Tumescent Solution Significantly Increases Phosphorylation of Perilipin in Adipocytes” indicates that the significant increase in this phosphyrylation process may have an effect on fat graft survival.1 This particular topic surfaces from time to time, and in the present report the authors showed that adipocytes collected before tumescent infiltration demonstrated that 10% of total perilipin was phosphorylated versus nearly 31% when tumescent solution was used. Since phosphorylation of perilipin renders the adipocyte more vulnerable to lipolysis, the authors recommended that the lowest possible concentrations of lidocaine and epinephrine be used. Why wouldn’t the explanation of these changes in phosphylation be increased because of …