Commentary on “Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statement”

Abstract

Typical colonic adenomatous polyposis as Familial Adenomatous Polyposis (FAP) and MutYH Associated Polyposis (MAP) are clinical entities with well-established phenotypical and molecular definitions. They are related to heterozygous germline pathogenic variants of the autosomic dominant APC gene, or to bi-allelic germline pathogenic variants of the autosomic recessive MutYH gene. They have clear recommendations for their management [ [1] Van Leerdam ME Roos VH van Hooft JE Dekker E Jover R Kaminski MF Latchford A Neumann H Pellisé M Saurin JC Tanis PJ Wagner A Balaguer F Ricciardiello L. Endoscopic management of polyposis syndromes: European society of gastrointestinal endoscopy (ESGE) guideline. Endoscopy. Sep 2019; 51 (doi:10.1055/a-0965-0605. Epub 2019 Jul 23. PMID:31342472): 877-895 Crossref PubMed Scopus (80) Google Scholar ]. Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statementDigestive and Liver DiseaseVol. 53Issue 4PreviewAn expert consensus panel convened by the Italian Association for Inherited and Familial Gastrointestinal Tumors (Associazione Italiana per lo Studio della Familiarità ed Ereditarietà dei Tumori Gastrointestinali, AIFEG) reviewed the literature and agreed on a number of position statements regarding the definition and management of polyposis coli without an identified pathogenic mutation on the APC or MUTYH genes, defined in the document as NAMP (non-APC/MUTYH polyposis). Full-Text PDF