Commentary on “Co-culture of infrapatellar fat pad derived MSCs and articular chondrocytes in plasma clot for cartilage tissue engineering”

Abstract

Because of its acellular and avascular nature, articular cartilage is challenging to regenerate, and despite considerable efforts in the field of tissue repair progress has been slow. In this issue of Cytotherapy, Arora and colleagues working in a goat model have made a step forward in optimizing the generation of cartilage tissue by co-culturing MSC derived from the infrapatellar fat pad with articular chondrocytes in plasma clots [ [1] Arora A. Sriram M. Kothari A. Katti D.S. Co-culture of infrapatellar fat pad derived MSCs and articular chondrocytes in plasma clot for cartilage tissue engineering. Cytotherapy. 2017; 19: 881-894 Abstract Full Text Full Text PDF Scopus (21) Google Scholar ]. Co-culture of infrapatellar fat pad–derived mesenchymal stromal cells and articular chondrocytes in plasma clot for cartilage tissue engineeringCytotherapyVol. 19Issue 7PreviewArticular cartilage repair is clinically challenging because of the hypo-cellular and avascular nature of cartilage tissue. In recent years, cartilage tissue engineering (CTE) has gained significant attention as an alternate strategy toward cartilage repair and regeneration. CTE uses cells, growth factors and biomaterials either alone or in combination to repair/regenerate articular cartilage tissue and its therapeutic outcome is strongly linked to these factors. Therefore, much effort has been devoted toward studying these individual factors and their combinations to effectively repair cartilage tissue [1]. Full-Text PDF