Abstract
Commentary on: Absence of Stimulus-driven Synchronization Effects on Sensory Perception in Autism: Evidence for Local Under-Connectivity
Highlights
Commentary on: Absence of Stimulus-driven Synchronization Effects on Sensory Perception in Autism: Evidence for Local Under
In 2007, we reported a method for perceptually assessing the impact of stimulus-driven synchronization of cortical ensembles that showed significant promise for perceptually measuring local connectivity[1]
Since a number of neurophysiological characteristics demonstrated in autism share the common theme of under-connectivity in the cerebral cortex, and one of the prominent theories of the cause of the dysfunctional connectivity in autism is based on distinct anatomical structures that differ between the autistic and the neurotypical cortex, we hypothesized that stimulus-driven synchronization of cortical ensembles would have little or no impact on temporal order judgement (TOJ) in individuals with autism
Summary
Autism is a pervasive developmental disorder that affects many aspects of the central nervous system, and a number of the deficits manifested in the disorder could be attributed to disruptions in functional connectivity. Numerous reports have indicated reduced functional connectivity on a large scale in the brains of individuals with autism, and we hypothesized that if the larger-scale aberrant dynamics in autism were due – at least in part – to a widespread propagation of the errors introduced at the level of local connectivity between minicolumns, aberrations in local functional connectivity should be detectable This was, what we demonstrated in our report – that local functional connectivity, as measured via TOJ observations in the presence and absence of synchronized conditioning stimuli – was much lower than that observed in typically developing controls. There have been a number of subsequent reports that are consistent with aberrant local connectivity in autism and a number of reports that provide further support for the measure that we described as being reflective of local under-connectivity
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