Commentary: Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription.

Francesca Di Rosa

doi:10.3389/fimmu.2016.00102

Abstract

Commentary: Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription.

Highlights

It has been thought that the bone marrow (BM) accomplishes this by sustaining a higher level of homeostatic proliferation of recirculating memory CD8 T cells than do spleen and lymph nodes (LN) in the steady state
They emphasize that results on memory CD8 T cell proliferation are discrepant and propose that the BM instead provides survival signals for resident memory CD8 T cells, as it does for plasma cells [3,4,5]
They show that BM memory CD8 T cells colocalize with stromal cells, expressing the prosurvival cytokine IL-7

Summary

Introduction

Starting from the article by Sercan Alp et al, this commentary revisits the data published so far on memory CD8 T cell proliferation in the BM and suggests that apparent discrepancies can be reconciled by a detailed analysis (see Table 1 and references therein). Sercan Alp and coworkers examined memory CD8 T cell proliferation or quiescence in mice by three methods, i.e., DNA content analysis, bromodeoxyuridine (BrdU) incorporation, and Ki67 staining [2].

Results

Conclusion