Abstract

Recently, Kenzo Tokunaga's group reported a novel restriction factor against HIV, MARCH8, which is highly expressed in terminally differentiated myeloid cells such as macrophages. Virus infection in macrophages was first observed in HIV-infected patients in the mid-1980s (Gyorkey et al., 1985; Ho et al., 1986; Koenig et al., 1986). Three decades have passed since then; however, the role of HIV-infected macrophages in AIDS pathogenesis remains controversial. Here, some potential implications of Tokunaga et al.'s study on this controversy will be addressed.

Highlights

  • Specialty section: This article was submitted to Virology, a section of the journal Frontiers in Microbiology

  • Kenzo Tokunaga’s group reported a novel restriction factor against HIV, membrane-associated RING-CH8 (MARCH8), which is highly expressed in terminally differentiated myeloid cells such as macrophages

  • Studies have used an SIV that lacks expression of its accessory protein, Vpx, which is critical for SIV/HIV-2 replication in macrophages and resting T lymphocytes and is important in activated T lymphocytes (Fujita et al, 2010, 2012; Baldauf et al, 2012)

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Summary

Introduction

Specialty section: This article was submitted to Virology, a section of the journal Frontiers in Microbiology. MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins by Tada, T., Zhang, Y., Koyama, T., Tobiume, M., Tsunetsugu-Yokota, Y., Yamaoka, S., et al (2015). Kenzo Tokunaga’s group reported a novel restriction factor against HIV, MARCH8, which is highly expressed in terminally differentiated myeloid cells such as macrophages.

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Conclusion

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