Abstract
Commentary: In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood.
Highlights
In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood By Faure MC, Khoueiry R, Quanico J, Acloque H, Guerquin MJ, Bertoldo MJ, Chevaleyre C, Ramé C, Fournier I, Salzet M, Dupont J, Froment P
Our position is that this statement is limited only to supra-physiological doses of metformin - in pregnant mice, and that it is inappropriate to extrapolate the observation to humans in whom such high doses of metformin is never recommended in a clinical setting
As reported in the Faure et al references, metformin is usually used at doses of approximately 20 to 30 mg/kg in humans for the treatment of diabetes or polycystic ovary syndrome (PCOS), both conditions being associated with female infertility and several pregnancy complications
Summary
In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood By Faure MC, Khoueiry R, Quanico J, Acloque H, Guerquin MJ, Bertoldo MJ, Chevaleyre C, Ramé C, Fournier I, Salzet M, Dupont J, Froment P. It was with great interest that we read the manuscript of Faure et al evaluating the impact of metformin during mice pregnancies [1]. We are concerned that the interpretation of the results yielded by this study may confuse readers due to the suggestion of a deleterious effect in the human male fetus.
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