Abstract
Commentary: Human brain organoid-on-a-chip to model prenatal nicotine exposure.
Highlights
Advances in three-dimensional (3D) neural culture models derived from human stem cells are revolutionizing the paradigm of neuroscience research
These 3D model systems offer a more faithful recapitulation of pivotal functions and cytoarchitectures of in-vivo neural tissues than conventional two-dimensional (2D) culture models and animal models (Zhuang et al, 2018). To establish these 3D neural models, brain organoids (Lee et al, 2017), and brain-on-a-chip systems (Haring et al, 2017) represent two typical approaches based on the strategies of developmental biology and bioengineering, respectively
Brain organoids are formed by sequential steps in neural development in vitro, including generation of embryoid bodies (EBs) from stem cells, induction of neuroectoderm in a dish, expansion of neuroepithelium in Matrigel, and organoid differentiation in suspension (Jo et al, 2016)
Summary
Advances in three-dimensional (3D) neural culture models derived from human stem cells are revolutionizing the paradigm of neuroscience research. Commentary: Human brain organoid-on-a-chip to model prenatal nicotine exposure. Human brain organoid-on-a-chip to model prenatal nicotine exposure by Wang, Y., Wang, L., Zhu, Y., and Qin, J.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
