Abstract
Commentary: HPV Catch-Up Vaccination Reduces the Prevalence of HPV 16 and 18 Infections and Cervical Disease: A Retrospective Study
Highlights
Human papillomavirus (HPV) vaccination is a success story
Our brief paper was a response to the article of Iacobone et al “Distribution of high-risk human papillomavirus genotypes and multiple infections in preneoplastic and neoplastic cervical lesions of unvaccinated women: a cross-sectional study”[2] in which the authors concluded that the widespread use of prophylactic HPV vaccines could significantly reduce the incidence of preneoplastic and neoplastic cervical lesions
We found a reduction in the prevalence both of HPV 16 and/or 18 from 53% (103 of 193 patients) to 16% (23 of 147 patients; 95% CI = 27.2%–45.6%, p < .0001) and of high grade cervical disease from 54% (104 of 193 patients) to 23% (34 of 147 patients; 95% CI = 20.8%–40.2%, p < .0001) in the bivalent HPV vaccine catch-up 2018–2019 cohort compared with the unvaccinated 2014–2015 cohort
Summary
Our brief paper (a letter to the editor 1) was a response to the article of Iacobone et al “Distribution of high-risk human papillomavirus genotypes and multiple infections in preneoplastic and neoplastic cervical lesions of unvaccinated women: a cross-sectional study”[2] in which the authors concluded that the widespread use of prophylactic HPV vaccines could significantly reduce the incidence of preneoplastic and neoplastic cervical lesions. Our study endorsed this statement by describing results from a retrospective cohort study in North Cumbria, England, United Kingdom (UK). We are currently looking at a third cohort, born from 1st September 1995, who were eligible for routine HPV vaccination at 12 to 13 years of age
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