Commentary: Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice.

Kun Zhao,Wei Sun,Yukang Mao

doi:10.3389/fcell.2021.654447

Abstract

Commentary: Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice.

Highlights

We recently read with interest the recent article by Liu et al (2020) regarding the pivotal regulation of activating transcription factor 4 (ATF4) in gut microbiota that is highly associated with the development of high-salt diet-induced hypertension in mice
The article demonstrates that activated ATF4 participated in the high-salt diet-induced elevated blood pressure (BP) by regulating gut microbiota composition and vitamin K2 (VK2) synthesis, shedding light on the novel mechanism underlying the effects of ATF4 on high-salt diet-induced hypertension from the perspective of intestinal metabolomics
Due to the existence of salt sensitivity and resistance, albeit different individuals may show different BP responses to dietary salt intake, the results of numbers of prospective cohort studies and retrospective studies showed that excessive salt intake (>4.6 g/day) can increase the incidence of adverse cardiovascular events, including cardiac interstitial and perivascular fibrosis, myocardial hypertrophy, and even heart failure, in both hypertensive and normotensive populations regardless of age and race (Strazzullo et al, 2009), indicating that high-salt diet independent of BP is an independent risk factor for cardiovascular disease

Summary

A Commentary on

Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice by Liu, T.

INTRODUCTION

DISCUSSION