Abstract
Commentary: Fc Gamma Receptors are Expressed in the Developing Rat Brain and Activate Downstream Signaling Molecules upon Cross-Linking with Immune Complex.
Highlights
During the past 20 years, a number of studies have reported IgG antibodies against viral or self-antigens in the developing human brain
Considering that antibodies linked to neurodevelopmental disorders have subsequently been shown to recognize intracellular antigens expressed in neurons and astrocytes[7], it is tempting to hypothesize that these autoantibodies could derail normal neurodevelopment by binding to their target antigens expressed on non-immune cells in the brain
We investigated the functional expression of these Fcγ receptors (FcγR) in vitro using primary co-cultures of neurons and astrocytes from neonatal rat pups
Summary
During the past 20 years, a number of studies have reported IgG antibodies against viral or self-antigens in the developing human brain. At first glance, such effects are expected to be mediated by IgG binding to its cognate Fcγ receptors (FcγR) on resident immune cells (such as microglia) in the brain and subsequent activation of local innate immune responses.
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