Abstract
GENERAL COMMENTARY article Front. Neurosci., 19 April 2016Sec. Neurodegeneration https://doi.org/10.3389/fnins.2016.00161
Highlights
Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
This publication is a review on the preclinical model used today for Parkinson’s disease that take in consideration both preclinical model based on neurotoxin or mutations associated to familial Parkinson’s disease (PD)
The question is why successful results in preclinical studies cannot be translated to clinical studies? In our opinion (i) The preclinical models based on exogenous neurotoxins such as 6-hydroxidopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been very useful and valuable tools to study mechanisms
Summary
Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience. The use of correct preclinical model to study the mechanisms and to test possible new therapies is essential to obtain successful results and new therapies.
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