Abstract
Commentary: "Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy"
Highlights
Epilepsy is a neurological disorder that is characterized by periodic seizures in affected individuals
Of the three human dynamin genes, DNM1 and DNM3 encode the only neuronal GTPases that participate in clathrin mediated synaptic vesicle endocytosis at the pre-synaptic and post-synaptic membrane respectively[3], while DNM2 is expressed ubiquitously[4]
It is probably because of this bit of good fortune that fitful remains the only animal model of DNM1 epileptic encephalopathy – as it seems that a delicate balance and interplay between isoforms is the difference between predisposition and full disease
Summary
Epilepsy is a neurological disorder that is characterized by periodic seizures in affected individuals. Very early studies on cellular mechanisms of epilepsy especially focused on inducing seizures in animal models by blocking synaptic activity using drugs that either block inhibitory neural networks[1] or activate voltage gated channels[2] to increase excitation. Of the three human dynamin genes, DNM1 and DNM3 encode the only neuronal GTPases that participate in clathrin mediated synaptic vesicle endocytosis at the pre-synaptic and post-synaptic membrane respectively[3], while DNM2 is expressed ubiquitously[4].
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