Abstract
Drugs which move relatively slowly in and out of body “compartments” thereby confer pharmacokinetic characteristics of a multicompartment system and elicit a considerably different time course of pharmacologic effect than do drugs which are distributed in the body extremely rapidly. The time course of pharmacologiC effects in multicompartment systems is considered here as a function of dose and site of action and duration of repetitive dosings. The durationdose and intensity‐time patterns thus obtained are consistent with the results of clinical studies. An appreciation of these relationships should be helpful in designing effective and safe dosage regimens.
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