Abstract
Commentary: Distribution of 5-HT1F Receptors in Monkey Vestibular and Trigeminal Ganglion Cells.
Highlights
Neurosurgery and Neurology Unit, Hospital das Clínicas, Federal University of Pernambuco, Cidade Universitária, Recife, Pernambuco, Brazil
Based on the assumption that a congruence exists between the expression of serotonin (5-hydroxytryptamine, 5-HT) receptors and vestibular pathways, Usman and Balaban [1] showed the distribution of 5-HT1F receptors in vestibular and trigeminal ganglia, including blood vessels, in the monkey
They discussed the relationship between the 5-HT1F receptor and 5-HT1B and 5-HT1D receptors, using previously data from their laboratory
Summary
Neurosurgery and Neurology Unit, Hospital das Clínicas, Federal University of Pernambuco, Cidade Universitária, Recife, Pernambuco, Brazil. A Commentary on Distribution of 5-HT1F Receptors in Monkey Vestibular and Trigeminal Ganglion Cells by Usman HO, Balaban CD. They logically explain possible interactions of triptans on 5-HT1F receptors (triptans activate 5-HT1B and 5-HT1D receptors) and point out that serotonin may be involved in the pathophysiology of some migrainous features (e.g., tinnitus and phonophobia) in vestibular migraine.
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